Bugs Allusions

EPISODE ALLUSIONS - Supernatural Wiki
EPISODE 108: BUGS

episode guide - Supernatural Wiki
Dean: Yeah, the whole Timmy-Lassie thing.

Lassie was a Emmy-winning TV show based on a boy (Timmy), the profound connection between him and his collie (Lassie) and his ability to come to the aid of those in trouble.

Sam: You watch Oprah?

The Oprah Winfrey Show is a long-running daytime talk show with many celebrity guests. The topics on the show are mainly geared towards women -- hence Sam's astonishment with Dean being familiar with the show.

Dean: Like Willard?

1971 movie (remade in 2003) about a lonely man who uses his unusual bond with the rats he lives with to exact revenge on the coworkers who put him down.

Creutzfeldt-Jakob Disease

The victim is first diagnosed with Creutzfeldt-Jakob disease (CJD), which is a rare and uncurable condition that degenerates brain matter. It is also related to BSE, commonly known as mad cow disease, which is why Sam refers to CJD as "human mad cow disease

Dean: (to Sam) You're like the blonde chick in The Munsters.

Marilyn Munster was the blonde-haired, all-American member of the Munster family, a family of monsters, and therefore considered herself the freak

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