- Where did all the people go?
- Sam may have more connection to the dark side than the boys suspected.
- Dwayne uses the exact same ritual to contact the demon that Meg uses in Scarecrow in season 1.
- When introducing himself and Sam, Dean says they are "Billy Gibbons, Frank Beard, U.S. Marshals." These are the names of two of the three members of the band ZZ Top. The third member is Dusty Hill.
- Sam asks Dean if he ever paid attention in school, to which Dean spouts a couple of facts. Sam retorts, "That wasn't school, Dean. That was Schoolhouse Rock," referencing a series of short cartoons that aired on ABC on Saturday mornings starting in 1973. Each show presented a brief animated sequence set to music that taught something about history, government, math, language, etc.
After Sam learns of his father's warning, he splits from Dean and starts hunting for others with his gift - or curse - of psychic powers. And someone's hunting for him: Gordon, the relentless vampire killer.