- What was the creature that Dean kills at the beginning of the episode?
- Of all the people in the tent, the Reverend chooses to heal Dean after Dean's made snarky remarks. He says it's because Dean has a mission to complete. So, maybe the Reverend really can "see" something!
- Did Sam and Dean do the right thing? (both having Dean healed and stopping Sue Ann before Layla could be healed)
- There is a way to control the Grim Reaper!
- Questions of faith come up for Dean.
- In this episode, it is revealed Dean is 27, but in the Pilot, he says he is 26. That means he has had a birthday, but they haven't mentioned it.
- While Roy is healing an old man, and the Reaper is taking the life of the young jogger, the song playing is "Don't Fear the Reaper" by Blue Oyster Cult.
- Blue Oyster Cult - "(Don't Fear) The Reaper"
- While lying in the hospital, Dean muses, "You ever actually watch daytime TV? It's terrible." This is an inside joke, seeing as Jensen Ackles used to play Eric Brady on the daytime drama Days of Our Lives.
The devil's down in Dixie - and he's driving one scary truck. Sam and Dean investigate when something wheeled, metallic and evil forces a series of African-American drivers off the road to their deaths.