- Are the demons stepping up their game, taking out planeloads of people a time?
- Can Sam perform an exorcism under unbelievable pressure?
- Dean is afraid of flying.
- Sam is till having nightmares about Jess, and he has not been sleeping much.
- Dean hums Metallica to calm himself down.
- This is the episode in which Dean's cell number was given (not a fake 555 number), and when called, a message said, "This is Dean Winchester. If this is an emergency, please leave a message. If you are calling about 11283, page me with your coordinates." (the message is no longer up)
- Black Sabbath - "Paranoid"
- Rush - "Working Man"
- Metallica - "Wherever I May Roam"
- Blue Sarenco - "Load Rage"
- A reference is made to The X-Files, which ran from 1993 to 2002. "The Truth is Out There" is the phrase shown at the end of the opening credits, and is basically the motto for the whole show.
- Dean says, "This goes way beyond floating over a bed or barfing pea soup," referring to the 1973 horror movie The Exorcist, in which a young girl is possessed by a demon. The movie was written by William Peter Blatty, who also wrote the novel it was based on.